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Iatrogenic Creutzfeldt-Jakob Disease at the Millenium Neurol 55:1075-1081, Brown,P.,et al, 2000 See this aricle in Pubmed Article Abstract The causes and geographic distribution of 267 cases of iatrogenic Creutzfeldt-Jakob disease (CJD) are here updated at the millennium. Small numbers of still-occurring cases result from disease onsets after longer and longer incubation perio ds following infection by cadaveric human growth hormone or dura mater grafts manufactured and distributed before the mid-1980s. the proportion of recipients acquiring CJD from growth hormone varies from 0.3 to 4.4% in different countries, and acquisitio n from dura mater varies between 0.02 and 0.05% in Japan (where most cases occurred). Incubation periods can extend up to 30 years, and cerebellar onsets predominate in both hormone and grafts recipients (in whom the site of graft placement had no effect on the clinical presentation). Homozygosity at codon 129 of the PRNP gene is over-represented in both forms of disease; it has no effect on the incubation period of graft recipients, but may promote shorter incubation periods in hormone cases. Knowled ge about potential high-risk sources of contamination gained during the last quarter century, and the implementation of methods to circumvent them, should minimize the potential for iatrogenic contributions to the current spectrum of CJD.

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(click to filter results - removes previous filter) dural graft,cadaveric growth hormone iatrogenic neurologic disorders Jakob-Creutzfeldt disease Jakob-Creutzfeldt disease,young adult review article

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